Detailed view for LOAG_02673

Basic information

TDR Targets ID: 951147
Loa Loa (eye worm), splicing factor 3a
Source Database / ID:  KEGG  

pI: 5.0955 | Length (AA): 796 | MW (Da): 87942 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00240   Ubiquitin family
PF01805   Surp module
PF12230   Pre-mRNA splicing factor PRP21 like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003723   RNA binding  
GO:0006396   RNA processing  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 100 2dt6 (A) 48 110 62.00 0 1 0.995546 -2.03
112 195 2dt7 (B) 135 217 72.00 0 1 0.916628 -0.54
689 794 1we6 (A) 9 108 34.00 0 1 0.490266 -0.49
690 794 1we7 (A) 8 112 43.00 0 1 0.67401 -0.63
738 787 2bwf (A) 19 71 38.00 0.29 1 0.490214 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128430)

Species Accession Gene Product
Arabidopsis thaliana AT1G14650   probable splicing factor 3A subunit 1
Arabidopsis thaliana AT1G14640   SWAP (Suppressor-of-White-APricot)/surp domain-containing protein
Babesia bovis BBOV_III005810   Surp module domain containing protein
Brugia malayi Bm1_01890   Surp module family protein
Candida albicans CaO19.12129   similar to S. pombe SWAP domain-containing SAP114 (SPAC22A12.09c ) pre-mRNA splicing factor
Candida albicans CaO19.4659   similar to S. pombe SWAP domain-containing SAP114 (SPAC22A12.09c ) pre-mRNA splicing factor
Caenorhabditis elegans CELE_W07E6.4   Protein PRP-21
Cryptosporidium hominis Chro.70247   splicing factor
Cryptosporidium parvum cgd7_2160   Pre-mRNA splicing factor SF3a. 2xSWAP domain protein
Dictyostelium discoideum DDB_G0272676   SWAP/Surp domain-containing protein
Drosophila melanogaster Dmel_CG16941   CG16941 gene product from transcript CG16941-RA
Echinococcus granulosus EgrG_000627300   splicing factor 3A subunit 1
Entamoeba histolytica EHI_058680   splicing factor, putative
Entamoeba histolytica EHI_198910   splicing factor, putative
Echinococcus multilocularis EmuJ_000627300   splicing factor 3A subunit 1
Homo sapiens ENSG00000099995   splicing factor 3a, subunit 1, 120kDa
Loa Loa (eye worm) LOAG_02673   splicing factor 3a
Mus musculus ENSMUSG00000002129   splicing factor 3a, subunit 1
Neospora caninum NCLIV_063290   hypothetical protein
Oryza sativa 4328860   Os02g0245000
Plasmodium berghei PBANKA_1301700   splicing factor 3A subunit 1, putative
Plasmodium falciparum PF3D7_1474500   splicing factor 3A subunit 1, putative
Plasmodium knowlesi PKNH_1244800   splicing factor 3A subunit 1, putative
Plasmodium vivax PVX_118605   hypothetical protein, conserved
Plasmodium yoelii PY02637   splicing factor, putative
Saccharomyces cerevisiae YJL203W   Prp21p
Schistosoma japonicum Sjp_0128200   Splicing factor 3 subunit 1, putative
Schistosoma japonicum Sjp_0021450   Splicing factor 3 subunit 1, putative
Schistosoma mansoni Smp_120320.1   spliceosome-associated protein
Schmidtea mediterranea mk4.000686.00   Spliceosome-associated protein, putative
Toxoplasma gondii TGME49_246500   surp module domain-containing protein
Theileria parva TP02_0389   hypothetical protein, conserved
Trichomonas vaginalis TVAG_285080   spliceosome associated protein, putative

Essentiality

LOAG_02673 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W07E6.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_W07E6.4 Caenorhabditis elegans slow growth wormbase
CELE_W07E6.4 Caenorhabditis elegans sterile wormbase
YJL203W Saccharomyces cerevisiae inviable yeastgenome
TGME49_246500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_02673 (Loa Loa (eye worm)), splicing factor 3a
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